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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Bioconjug Chem. 2008 Jul 12;19(8):1579–1587. doi: 10.1021/bc800110y

Table 1.

Biodistribution of different anti-HER2 Affibody conjugates after iv injection in NMRI mice.

Uptake, % IA/g a
4 h pi
 24 h pi
111In-CHX-A” 111In-DOTA- 111In-CHX-A” 111In-CHX-A” 111In-DOTA- 111In-CHX-A”
DTPA-Z2395-C Z2395-C DTPA-Z342 DTPA-Z2395-C Z2395-C DTPA-Z342
blood 0.069 ± 0.003 c, d 0.18 ± 0.07 0.04 ± 0.01 c 0.023 ± 0.003 c, d 0.05 ± 0.01 0.011 ± 0.002 c
lung 0.34 ± 0.04 0.27 ± 0.04 0.24 ± 0.06 0.158 ± 0.009 d 0.14 ± 0.03 0.107 ± 0.008
liver 1.1 ± 0.1 d 1.01 ± 0.05 0.32 ± 0.07 c 0.65 ± 0.05 c, d 0.85 ± 0.01 0.17 ± 0.03 c
spleen 0.30 ± 0.04 0.32 ± 0.03 0.2 ± 0.1 0.21 ± 0.02 d 0.23 ± 0.02 0.13 ± 0.02 c
kidney 234 ± 20 c 183 ± 12 217 ± 21 135 ± 9 d 126 ± 12 109 ± 8
muscle 0.08 ± 0.01 c 0.055 ± 0.006 0.06 ± 0.04 0.05 ± 0.01 d 0.035 ± 0.003 0.029 ± 0.009
bone 0.38 ± 0.08 c 0.15 ± 0.03 0.4 ± 0.3 0.245 ± 0.03 c 0.099 ± 0.008 0.17 ± 0.05 c
intestineb 2.0 ± 0.4 2.3 ± 0.7 1.9 ± 0.6 0.87 ± 0.02 0.8 ± 0.2 0.6 ± 0.2
carcassb 3.8 ± 0.4 3.4 ± 0.6 2.6 ± 1.0 2.3 ± 0.4 d 1.9 ± 0.2 1.2 ± 0.1 c
a

data presented as average ± SD (n = 4) of per cent of injected activity per gram (% IA/g);

b

for intestine (together with content) and carcass, data presented as per cent of injected activity per whole sample (% IA);

c

significant difference (p < 0.05) with 111In-DOTA-Z2395-C at the same time point;

d

significant difference (p < 0.05) with 111In-CHX-A” DTPA-Z342 at the same time point;