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. Author manuscript; available in PMC: 2008 Oct 6.
Published in final edited form as: Methods Enzymol. 2004;378:31–67. doi: 10.1016/S0076-6879(04)78003-9

Table 1.

Relationship between rat and human AKR1C family members

Nomenclature Enzyme Other Names Percent Sequence Identity Tissue Distribution
AKR1C9 Rat dihydrodiol dehydrogenase 3α-HSD 67% Liver
AKR1C1 Human dihydrodiol dehydrogenase 1 20α(3α)HSD 84.1% Lung> Liver> Testis>Mammary Gland
AKR1C2 Human dihydrodiol dehydrogenase 2 Type 3 3α-HSD/bile acid binding protein 99.4% Lung & Liver > Prostate, Testis & Mammary Gland
AKR1C3 Human dihydrodiol dehydrogenase X Type 2 3α-HSD/Type 5 17β-HSD 87.9% Mammary gland > prostate> liver >lung
AKR1C4 Human dihydrodiol dehydrogenase 4 Type 1 3α-HSD Chlordecone reductase 86% Liver specific
AKR1A1 Human dihydrodiol Dehydrogenase 3 Aldehyde reductase 46% Ubiquitous