Abstract
Hematological parameters, including serum ferritin, were estimated in a healthy Nigerian population and in patients with other clinical conditions. The hematological values fell within the reported range for healthy populations in other parts of the world. The mean serum ferritin value in the male population was 72.4 ng/mL compared with the female value of 34.3 ng/mL. There was a strong correlation between the percentage of transferrin saturation and the serum ferritin level in males only (r = .40, P < .002).
In patients with sickle cell disease, SC-group patients had a significantly higher hemoglobin concentration (P < .001) than the SS group. However, the SS group had higher values for mean corpuscular hemoglobin, mean corpuscular volume, and transferrin saturation than the SC group. Also, the mean ferritin level in the SS group (296.3 ± 61.9 ng/mL) was significantly higher (P < .01) than in the SC group (mean 180.8 ± 97.2 ng/mL).
When sickle cell anemia was complicated by chronic osteomyelitis, the ferritin level was much higher (mean, 1,470 ng/mL) than at the steady state. Finally, in patients with leukemia, serum ferritin levels were much higher than in the healthy population.
Full text
PDF




Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Addison G. M., Beamish M. R., Hales C. N., Hodgkins M., Jacobs A., Llewellin P. An immunoradiometric assay for ferritin in the serum of normal subjects and patients with iron deficiency and iron overload. J Clin Pathol. 1972 Apr;25(4):326–329. doi: 10.1136/jcp.25.4.326. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Araba A. B. A survey of haematological variables in 600 healthy Nigerians. Niger Med J. 1976 Jan;6(1):49–53. [PubMed] [Google Scholar]
- BAINTON D. F., FINCH C. A. THE DIAGNOSIS OF IRON DEFICIENCY ANEMIA. Am J Med. 1964 Jul;37:62–70. doi: 10.1016/0002-9343(64)90212-8. [DOI] [PubMed] [Google Scholar]
- Bentley D. P., Williams P. Serum ferritin concentration as an index of storage iron in rheumatoid arthritis. J Clin Pathol. 1974 Oct;27(10):786–788. doi: 10.1136/jcp.27.10.786. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cook J. D., Lipschitz D. A., Miles L. E., Finch C. A. Serum ferritin as a measure of iron stores in normal subjects. Am J Clin Nutr. 1974 Jul;27(7):681–687. doi: 10.1093/ajcn/27.7.681. [DOI] [PubMed] [Google Scholar]
- Finch C. A. Pathophysiologic aspects of sickle cell anemia. Am J Med. 1972 Jul;53(1):1–6. doi: 10.1016/0002-9343(72)90110-6. [DOI] [PubMed] [Google Scholar]
- Hussain M. A., Davis L. R., Laulicht M., Hoffbrand A. V. Value of serum ferritin estimation in sickle cell anaemia. Arch Dis Child. 1978 Apr;53(4):319–321. doi: 10.1136/adc.53.4.319. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jacobs A., Miller F., Worwood M., Beamish M. R., Wardrop C. A. Ferritin in the serum of normal subjects and patients with iron deficiency and iron overload. Br Med J. 1972 Oct 28;4(5834):206–208. doi: 10.1136/bmj.4.5834.206. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jacobs A., Waters W. E., Campbell H., Barrow A. A random sample from Wales. 3. Serum iron, iron binding capacity and transferrin saturation. Br J Haematol. 1969 Dec;17(6):581–587. doi: 10.1111/j.1365-2141.1969.tb01409.x. [DOI] [PubMed] [Google Scholar]
- Jones P. A., Miller F. M., Worwood M., Jacobs A. Ferritinaemia in leukaemia and Hodgkin's disease. Br J Cancer. 1973 Mar;27(3):212–217. doi: 10.1038/bjc.1973.26. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lipschitz D. A., Cook J. D., Finch C. A. A clinical evaluation of serum ferritin as an index of iron stores. N Engl J Med. 1974 May 30;290(22):1213–1216. doi: 10.1056/NEJM197405302902201. [DOI] [PubMed] [Google Scholar]
- PRITCHARD J. A., MASON R. A. IRON STORES OF NORMAL ADULTS AND REPLENISHMENT WITH ORAL IRON THERAPY. JAMA. 1964 Dec 7;190:897–901. doi: 10.1001/jama.1964.03070230033008. [DOI] [PubMed] [Google Scholar]
- Parry D. H., Worwood M., Jacobs A. Serum ferritin in acute leukaemia at presentation and during remission. Br Med J. 1975 Feb 1;1(5952):245–247. doi: 10.1136/bmj.1.5952.245. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Peterson C. M., Graziano J. H., de Ciutiis A., Grady R. W., Cerami A., Worwood M., Jacobs A. Iron metabolism, sickle cell disease, and response to cyanate. Blood. 1975 Oct;46(4):583–590. [PubMed] [Google Scholar]
- Serjeant G. R., Serjeant B. E. A comparison of erythrocyte characteristics in sickle cell syndromes in Jamaica. Br J Haematol. 1972 Aug;23(2):205–213. doi: 10.1111/j.1365-2141.1972.tb03473.x. [DOI] [PubMed] [Google Scholar]
- Siimes M. A., Addiego J. E., Jr, Dallman P. R. Ferritin in serum: diagnosis of iron deficiency and iron overload in infants and children. Blood. 1974 Apr;43(4):581–590. [PubMed] [Google Scholar]
- Ukaejiofo E. O., Isaacs-Sodeye W. A., Adigun E. S., Ipadeola A. Normal haematological values in adult Nigerians. Niger Med J. 1979 Jan;9(1):117–119. [PubMed] [Google Scholar]
- Williams H. L., Conrad M. E. A one-tube method for measuring the serum iron concentration and unsaturated iron-binding capacity. J Lab Clin Med. 1966 Jan;67(1):171–176. [PubMed] [Google Scholar]
- Worwood M., Summers M., Miller F., Jacobs A., Whittaker J. A. Ferritin in blood cells from normal subjects and patients with leukaemia. Br J Haematol. 1974 Sep;28(1):27–35. [PubMed] [Google Scholar]
