Table 4.

Association of the Lead SNPs with Plasma Levels of Liver Enzymes in the CoLaus Study

SNP	Nearest Gene	ALT		AST		ALP		GGT
		Beta (% 95 CI)	p Value	Beta (% 95 CI)	p Value	Beta (% 95 CI)	p Value	Beta (% 95 CI)	p Value
rs11597390	CPN1	−0.043 (−0.062−0.023)	1.4 × 10−5	−0.022 (−0.035−0.009)	0.0009	−0.011 (−0.023−0.001)	0.08	−0.004 (−0.008−0.0001)	0.04
rs2281135	PNPLA3	0.064 (0.041–0.087)	2.6 × 10−8	0.035 (0.020–0.050)	5.7 × 10−6	−0.005 (−0.019−0.010)	0.51	−0.001 (−0.006−0.003)	0.61
rs1169313	HNF1A	0.002 (−0.016–0.019)	0.86	0.001 (−0.011–0.012)	0.92	0.013 (0.002–0.024)	0.03	−0.006 (−0.009−0.002)	0.0009
rs4820599	GGT1	−0.002 (−0.021−0.017)	0.82	0.003 (−0.009–0.016)	0.6	0.006 (−0.006–0.018)	0.36	0.003 (−0.001–0.007)	0.09
rs1780324	NBPF3-ALPL	0.01 (−0.007–0.027)	0.26	0.015 (0.003–0.026)	0.01	0.031 (0.020–0.042)	5.6 × 10−8	0.003 (−0.001–0.006)	0.14
rs9467160	GPLD1	0.003 (−0.018–0.024)	0.76	−0.003 (−0.017−0.011)	0.66	0.031 (0.018–0.044)	5.6 × 10−6	0.001 (−0.003–0.005)	0.65
rs657152	ABO	0.012 (−0.007–0.030)	0.21	−0.001 (−0.013−0.011)	0.88	−0.061 (−0.072−0.050)	2.5 × 10−25	0.001 (−0.002–0.005)	0.57
rs12355784	JMJD1C	−0.003 (−0.021−0.015)	0.72	0.001 (−0.011–0.013)	0.83	0.026 (0.014–0.037)	1.6 × 10−5	0.003 (−0.001–0.007)	0.1