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. Author manuscript; available in PMC: 2008 Oct 6.
Published in final edited form as: Anesthesiology. 2008 Aug;109(2):339–348. doi: 10.1097/ALN.0b013e31817f4ce0

Figure 2.

Figure 2

Intracellular Hsp70 blocks activation of the transcription factor NFκB reducing production of downstream inflammatory mediators. Three mechanisms have been described, inhibition of activation of IKK, inhibition of ubiquitination of TRAF6 and stabilization of the inhibitory complex with IκB. TRAF=Tumor Necrosis Factor Associated Factor 6; ubi=ubiquitination; IKK= IκB kinase; IκB= inhibitor of NFκB, p50-p65 are two of the NFκB subunits which after release move to the nucleus to act as a transcription factor resulting in activation of inflammatory genes. MMP=matrix metalloproteinase, iNOS=inducible nitric oxide synthase. The Y shaped bracket from Hsp70 to the IκB:NFκB complex is meant to indicate binding and stabilization of the complex.