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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: J Mol Cell Cardiol. 2008 May 15;45(2):185–192. doi: 10.1016/j.yjmcc.2008.04.014

Figure 2.

Figure 2

Figure 2

Figure 2

Figure 2

Over-expression or down-regulation of a subset of miRNAs in NRVMs regulates β-AR changes in gene expression. (A) Changes in miR-92, miR-133b and miR-100 abundance upon transfection with microRNA mimics or microRNA inhibitors. miRNA abundance was determined by RT-PCR. (B-D) Changes in fetal gene expression in NRVMs transfected with microRNA mimic or microRNA inhibitors. Cells were treated with 10-7M ISO (black bars) 24 hours after transfection and harvested 48 hours after treatment. Gene expression was measured by RT-PCR. Results were normalized to 18S rRNA expression levels and were compared to cells transfected with a control mimic or inhibitor, defined as 1 (line at 1). The graphs represent an average of 3-4 individual experiments.