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. 2008 Aug 27;28(35):8709–8723. doi: 10.1523/JNEUROSCI.2077-08.2008

Figure 6.

Figure 6.

COMT specifically modulate PFC CaMK superfamily components. A, B, CaMKII protein immunoreactivity levels in the PFC of COMT+/+, COMT+/−, COMT−/− (A) and control and COMT-Val-tg mice (B) by immunoblot analysis. n = 10–16 per group. *p < 0.05 versus proper wild-type control group. C–F, Normalized expression levels of CaMKII mRNA α- (C), β- (D), δ- (E), and γ- (F) subunits in the PFC of COMT+/+, COMT+/− and COMT−/− mice. n = 9–10 per group. *p < 0.05; **p < 0.005 versus COMT+/+ mice. G–I, Normalized expression levels of CaMKKβ mRNA (G) and protein, heavier (H), and lighter (I) band by immunoblot analysis in the PFC of COMT+/+, COMT+/−, and COMT−/− mice. n = 9–10 per group. *p < 0.05 versus COMT+/+ mice. The CaMKKβ heavier band has been reported to be brain-specific (Anderson et al., 1998). L, M, Normalized expression levels of CaMKIV mRNA (L) and protein (M) in the PFC of COMT+/+, COMT+/−, and COMT−/− mice. n = 9–28 per group. *p < 0.05 versus COMT+/+ mice. Results are expressed as percentage of the COMT+/+ group for each experiment. Values represent mean ± SEM.