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Survey of Substituents and Their Effects on the Ratio of Ortho versus Ipso Cyclization
 | |||||
|---|---|---|---|---|---|
| entry | n | R1 | amide | A/B ratio | yield of A three steps |
| 1 | 0 | -H |
|
<1:99 | 0% |
| 2 | 1 | -H |
|
18:82 | 7% |
| 3 | 1 | -H |
|
43:57 | 28% |
| 4 | 1 | -Br |
|
92:8 | 49% |
| 5 | 1 | -Br |
|
66:33 | 40% |
| 6 | 1 | -Br |
|
46:54 | 14% |
