Table 2.
Baseline and 3 month data for 72 subjects who completed participation in Keep the Beat
| Parameter | Baseline | 3 Months | P Value |
|---|---|---|---|
| Vital Signs | |||
| Body mass index (kg/m2) | 28.8 ± 7.0 | 28.5 ± 6.9 | 0.0565 |
| Systolic blood pressure (mm/Hg) | 117 ± 14 | 118 ± 13 | 0.4825 |
| Diastolic blood pressure (mm/Hg) | 73 ± 9 | 71 ± 9 | 0.0478 |
| Resting heart rate (beats/min) | 70 ± 10 | 69 ± 11 | 0.7814 |
| Lab Values | |||
| Total cholesterol (mg/dL) | 189 ± 35 | 181 ± 36 | 0.0131 |
| Low-density cholesterol (mg/dL) | 122 ± 31 | 116 ± 32 | 0.0044 |
| High-density cholesterol (mg/dL) | 60 ± 14 | 58 ± 17 | 0.0277 |
| Triglycerides (mg/dL) | 109 ± 74 | 106 ± 69 | 0.5159 |
| C-reactive protein (mg/dL) | 3.5 ± 4.4 | 4.2 ± 6.9 | 0.4788 |
| Glucose (mg/dL) | 94 ± 23 | 95 ± 17 | 0.0435 |
| Insulin (μunit/mL) | 11 ± 8 | 12 ± 8 | 0.0687 |
| Homeostasis model assessment of insulin sensitivity (HOMA Index) | 2.67 ± 2.15 | 3.01 ± 2.63 | 0.1901 |
| Estradiol* (pg/mL) | 77 ± 76 | 72 ± 65 | 0.7567 |
| Follicle-stimulating hormone * (IU/L) | 28 ± 32 | 27 ± 30 | 0.7323 |
| Endothelial and Progenitor Cell Testing | |||
| Flow-mediated dilation (% change) | 7.8 ± 3.4 | 8.5 ± 3.0 | 0.0096 |
| Endothelial progenitor cell colonies/well | 37 ± 47 | 54 ± 55 | 0.0003 |
| CD 133/VEGFR-2** (cells/mL) | 3 ± 4 | 19 ± 13 | < 0.0001 |
| Treadmill Exercise Data (Bruce protocol) | |||
| Exercise duration (sec) | 544 ± 137 | 599 ± 143 | 0.0001 |
| Peak heart rate (beats/min) | 172 ± 13 | 174 ± 13 | 0.1672 |
| Respiratory exchange ratio | 1.2 ± 0.1 | 1.2 ± 0.1 | 0.9886 |
| Peak oxygen consumption (mL O2/kg/min) | 28.7 ± 6.9 | 30.1 ± 7.0 | 0.0028 |
| Ventilatory threshold | 28.7 ± 3.3 | 29.7 ± 3.6 | < 0.0001 |
| Anaerobic threshold | 19.9 ± 3.9 | 19.7 ± 3.9 | 0.3068 |
*
Women Only (N=58)
**
Subset of Participants with Flow Cytometry Data (N=21)