Table I.

Potency of CP-4055 and combination partners in human leukemia cells.

	HL-60		U937
Drug	IC50 (nM)	N	IC50 (nM)	N
CP-4055	13,387 ± 1428	24	710 ± 78	14
Cloretazine	136,150 ± 11,146	7	59,996 ± 13,852	7
Idarubicin	12.1 ± 0.6	8	30 ± 5	7
Gemcitabine	9.4 ± 0.7	18	23 ± 2	10
Irinotecan	4742 ± 253	8	3823 ± 518	7
Topotecan	20.2 ± 1.0	7	34 ± 2	7
Cytarabine	2989 ± 322	5	167 ± 29	4