Table II.
Combination index at the IC50 in human leukemia cells.
| Molar ratio | N | CI | |
|---|---|---|---|
| HL-60 Combination | |||
| Cytarabine + Gemcitabine | 1:0.01 | 3 | 0.39 ± 0.01 |
| CP-4055 + Gemcitabine | 1:0.0025 | 11 | 0.41 ± 0.01 |
| CP-4055 + Topotecan | 1:0.00125 | 6 | 0.78 ± 0.01 |
| CP-4055 + Irinotecan | 1:0.125 | 6 | 0.81 ± 0.07 |
| CP-4055 + Idarubicin | 1:0.0025 | 6 | 0.88 ± 0.09 |
| CP-4055 + Cloretazine | 1:10 | 6 | 0.91 ± 0.08 |
| Cloretazine + Gemcitabine | 1:0.00025 | 3 | 1.10 ± 0.11 |
| Cloretazine + Idarubicin | 1:0.00025 | 3 | 1.20 ± 0.03 |
| Idarubicin + Gemcitabine | 1:1 | 3 | 1.51 ± 0.04 |
| CP-4055 + Cloretazine + Gemcitabine | 1:10:0.001 | 2 | 0.36 ± 0.07 |
| CP-4055 + Idarubicin + Gemcitabine | 1:0.001:0.001 | 2 | 0.30 ± 0.17 |
| CP-4055 + Cloretazine + Idarubicin | 1:10:0.001 | 2 | 0.92 ± 0.15 |
| U937 combination | |||
| CP-4055 + Gemcitabine | 1:0.02 | 8 | 0.82 ± 0.04 |
| CP-4055 + Cloretazine | 1:40 | 6 | 0.94 ± 0.10 |
| Cytarabine + Gemcitabine | 1:0.2 | 3 | 1.00 ± 0.05 |
| CP-4055 + Irinotecan | 1:2 | 4 | 1.11 ± 0.02 |
| CP-4055 + Topotecan | 1:0.02 | 4 | 1.11 ± 0.06 |
| CP-4055 + Idarubicin | 1:0.01 | 6 | 1.16 ± 0.11 |