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Pharmacodynamic model parameters for the simultaneous combination of CP-4055 plus gemcitabine.*
| HL-60 | U937 | |||||
|---|---|---|---|---|---|---|
| Drug | n | Log(k) | R2 | n | Log(k) | R2 |
| CP-4055 | 1.78 | 9.11 | 0.86 | 1.09 | 4.47 | 0.84 |
| Gemcitabine | 1.23 | 1.59 | 0.99 | 1.06 | 2.89 | 0.87 |
Based on log(T) = n log(C) + log(k), where C is the IC50 concentration, n is the concentration coefficient, k is the exposure constant and R2 is the Pearson linear correlation coefficient.
