FIGURE 10.

Effect of myotrophin treatment (wild type or E33A mutant) on cell surface area of neonatal rat ventricular cell. The cells were treated with either wild type (WT) or with E33A myotrophin protein and compared with untreated control cells. The cells were treated for 72 h, fixed and micrographs were taken randomly from different portions of the slide. The cell area was measured using ImagePro 6.1 software. The data (means ± S.E.) averaged from nine individual measurements for each group are expressed in mm². Wild type myotrophin-treated cells showed a significant (p < 0.001) increase in cell surface area compared with untreated and E33A-treated cells.