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Steady-state kinetic parameters for ICL bypass by E. coli pol IV
ND, non-damaged DNA substrate.
| DNA substrate | Primer | dNTP | kcat | Km | kcat/Km | Relative efficiency |
|---|---|---|---|---|---|---|
| min-1 | mm | μm-1 min-1 | ||||
| ND | -1 | dCTP | 0.90 ± 0.08 | 168 ± 30 | 5.4 × 10-3 | 1 |
| ICL4 | -1 | dCTP | 0.020 ±0.001 | 183 ± 18 | 0.11 × 10-3 | 0.02 |
| ND | 0 | dGTP | 3.9 ± 0.2 | 85 ± 8 | 46 × 10-3 | 1 |
| ICL4 | 0 | dGTP | 0.75 ± 0.02 | 36 ± 3 | 21 × 10-3 | 0.46 |
