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. 2008 Sep 18;1(2-3):168–174. doi: 10.1242/dmm.000109

Fig. 1. Gentic epistatis analysis in the Drosophila eye indicates that Parkin and Omi function downstream of Pink1.

Fig. 1.

Scanning electron microscopy (SEM) images of fly eyes expressing indicated transgenes. (A) GMR-GAL4 driver alone reveals the wild-type eye morphology of regularly arrayed ommatidia. Overexpression of pink1 causes a rough eye phenotype (B) that is partially suppressed in parkin mutants (C). (D) Overexpression of both pink1 and parkin shows an enhanced phenotype. (E) Overexpression of both pink1 and omi also shows a strong interaction. (F) omi mutants suppress the pink1 rough eye. (G) Parkin and Omi do not genetically interact. (H) parkin mutants do not suppress the Pink1/Omi interaction, and (I) omi mutants do not suppress the Pink1/Parkin interaction. (J) Loss of both parkin and omi completely suppresses the pink1 overexpression phenotype. (K) Mean + s.d. from more than 50 flies of specified genotypes, scored blind for relative roughness (see Methods).