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. Author manuscript; available in PMC: 2009 Aug 15.
Published in final edited form as: Gene. 2008 May 23;420(1):34–41. doi: 10.1016/j.gene.2008.05.008

Figure 4. Regulation of Fas expression differs in p53-deficient cells during the early response to DNA damage.

Figure 4

A. A scheme of the p53-dependent response to DNA damage. p53 induces expression of the Fas gene, leading to an increased amount of Fas receptor molecules on the cellular surface, thus making the cell more sensitive to FasL-mediated apoptosis. B. A scheme of the early response to DNA damage in the absence of p53. In p53-deficient cells, the total expression of the Fas gene does not change and activation of AS leads to increased expression of the soluble isoform of the receptor. This results in a decreased amount of Fas receptor on the cellular surface, accompanied by the appearance of the soluble anti-apoptotic isoform in the intercellular space, and resulting in protection of the cell from FasL-mediated apoptosis.