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. Author manuscript; available in PMC: 2009 Oct 15.
Published in final edited form as: J Immunol. 2008 Oct 15;181(8):5768–5774. doi: 10.4049/jimmunol.181.8.5768

Figure 6.

Figure 6

IGF-1 potentiates IgM and IgG production, both in B cells from patients with GD and in those from control donors. IgM and IgG were assayed after 12 days in culture stimulated with CpG and/or IGF-1. (A) IGF-1 (10 ng/ml) alone or in combination with CpG (2 μg/ml), significantly increase IgM production by GD and control B cells. (B) CpG and IGF-1, used as single agents enhanced IgG production by B cells from both sources (*p<0.05 vs US). The combination of CpG and IGF-1 significantly increases IgG production only in B cells from patients with GD compared with treatment with either single agent (**p<0.01). Results are expressed as the mean ± SE of 5 independent experiments.