Pedigree and genetic analysis. Black symbols indicate those clinically affected with Möbius’ syndrome; = indicates consanguinity. References within text refer to the generation number (roman numeral) and position within generation (arabic numeral). Genotyping data and schematic segregating haplotype bars for markers spanning the (A) HOXA1, (B) FEOM2, (C) FEOM1, and (D) FEOM3 loci are shown below the symbol for each individual. The position of the (A) HOXA1, (B) PHOX2A, and (C) KIF21A genes is indicated, and a negative sign (−) indicates the individual(s) sequenced for the specific gene. The FEOM3 disease gene has not yet been identified.