Fig. 1.

Oral FTI treatment leads to increased levels of the biomarker non-farnesylated HDJ-2. (A) Protein was extracted from mouse livers at the time of euthanasia. Western blotting of liver protein extracts demonstrates a dose-related increase in levels of non-farnesylated HDJ-2 (Upper) in comparison with farnesylated HDJ-2 (Lower) with FTI treatment. (B) All study mice are represented on a plot demonstrating the increasing levels of non-farnesylated HDJ-2 with increasing dose of FTI. Triangles represent transgenic G608G LMNA mice and circles represent non-transgenic WT controls.