Figure 1.

Expression pattern of select RNA binding proteins during development. (A,B,E,F,H,I,K,L,N,O,Q,R,T,U,W,X) stage 20 embryos from dorso-anterior and dorsal views. (C,D,G) stage 25 tailbud embryos; (J,M,P,S,V,Y) stage 32 tadpoles. (A–G) were cleared in BB/BA. (A–D), Rbmx/hnRnpG; (A,B) stage 20 embryos show hnRnpG expression all along the anterior-posterior extent of the neural tube with strong expression in the anterior neural domains, and placodal regions; (C,D) stage 25 tailbud embryos; Rbmx/HnRnpG is expressed in the fore-, mid-, and hindbrain, neural crest tissue of the branchial arches, and in the somites. (E,F) stage 20 embryos; Rbm4 is expressed in the neural tube, and at the tailbud stage. (G) Rbm4 is expressed in the brain and eye. (H–J) Sfrs3 is expressed ubiquitously, but expression is enriched in the neural tube and somites at the neural tube stage, and this pattern is maintained into the tadpole stage. (K–M) SRrp35 is expressed in the neural tube and weakly in the somites along the entire anterior-posterior axis. (N–P) Sam68 is expressed along the entire anterior-posterior axis of the neural tube and in the neural crest adjacent to the hindbrain. (Q–R) hnRnpL expression is present in the neural tube at stage 20 but is restricted to more anterior neural regions in the tadpole (S). (T–V) hnRnpC is expressed at low levels throughout the embryo early and is slightly enriched in the neural tube and somites at stage 20 (T,U), but is restricted primarily to the neural tube and somites by the tadpole stage (V). Expression of hnRnpA1 is enriched in the neural tube and somites at stage 20, and this expression is maintained into the tadpole stage (W–Y).