Table 1.
Summary of isolated clones and overexpression phenotypes. Phenotype categories: AD: Anterior Defects, CED: Convergent Extension Defects, DD: Dorsal Defects, GD: Gastrulation Defects, K: Kinked, NM: Neural Mispatterning, PD: Pigmentation Defects, SA: Secondary Axis, SB: Spina Bifida, TD: Trunk Defects, V: Ventralized.
| Group | Gene name | Clone ID | BLASTn | Phenotype |
|---|---|---|---|---|
| A. Secreted | Derriere | 21L16 | BC073508 | V |
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| ||||
| B. Transcription | Dbx1 | 5H19 | AF253504 | NM, K |
| Groucho4 | 5D11 | BC077582 | GD, PD | |
| Irx3 | 10D1 | AF027175 | SB, NM | |
| Kaiso | 5L24 | AF420316 | AD | |
| Not | 6E19 | Z19577 | AD, PD | |
| NRcoACT5 | 3H18 | BC042244 | NM, SB | |
| Oct91 | 21C4 | M60077 | PD, DD, NM | |
| Otx5 | 6O13 | AB034702 | CED | |
| OtxA | 4L2 | BC077357 | GD, TD, SB | |
| Sox2 | 18F19 | AF005476 | AD, GD | |
| SoxD | 20O19 | NM_001087732 | GD | |
| YB3 | 6A23 | BC042217 | TD, NM | |
|
| ||||
| C. mRNA splicing | hnRNPA1a | 8G20, 18D19 | BC045260 | NM |
| hnRNPA1 | 1I22 | BC072090 | K, NM, PD | |
| hnRNPA/B | 11N7 | BC043814 | K, AD | |
| hnRNPC(C1/C2) | 21M4 | BC041534 | K, AD, TD | |
| hnRNPD-like/JKTBP | 6D15, 14F20 | BC045124 | TD | |
| hnRNPG/RbmX | 2M5, 3A24 | BC070649 | K, AD, NM | |
| hnRNPL | 3E24 | BC077493 | NM | |
| SF-RS2/SF-SC35 | 5F17, 8A9 | BC045229 | AD, GD | |
| SF-RS3/SRp20 | 5L3 | BC046661 | GD, NM | |
| SRrp35/SR-repressor protein | 18L21 | BC084231 | K, AD, TD | |
| SF-RS10/Transformer2 | 14D18 | BC108873 | K, NM | |
| SFrs130/SRrp130 | 4D6 | BC072160 | PD | |
| YTH-domain family 2 protein | 14L18 | BC068959 | AD, TD | |
|
| ||||
| D. RNA binding | CIRP1/cold-inducible RNA binding protein-1 | 14J20 | AF278702 | DD |
| CIRP2/cold inducible RNA-binding protein-2 | 5P11,18E20 | BC054250 | GD | |
| DAZAP2 | 18E1 | BC042215 | GD | |
| FUS/TLS/pigpen | 6A17 | BC044319 | AD, ND | |
| KH-domain RNA-binding protein/Sam68 | 3N16 | AY260734 | NM, K, GD | |
| RBM4 | 3I22 | CR942584.2 | GD, NM | |
| Survival motor neuron protein (SMN) | 3G20 | BC068721 | NM | |
|
| ||||
| E. DNA binding | Histone H2A.Zl2 | 5H3 | BC044011 | NM |
| Pol delta interacting protein 3 | 18J21 | BC073024 | NM | |
| POLD3 p66 subunit | 10P1 | NM_001089291.1 | K, AD | |
|
| ||||
| F. Intracellular | Acidic nuclear phosphoprotein B (Anp32b) | 3E20,14B20 | BC110946.1 | TD, NM |
| Adaptin ear-binding coat-associated protein 2 (NECAP-2) | 5D7 | BC079728 | GD, K | |
| Adenine nucleotide translocase | 5L7 | BC043821 | GD | |
| Anaphase promoting complex subunit 11 | 5P7 | BC088720 | NM, AD, GD | |
| Claudin7L1 | 1G22 | AB072910 | GD, AD | |
| Dishevelled | 18P21 | BC090218.1 | DD, SA, PD | |
| MARCKS-like | 5F7 | AF187864 | GD | |
| Par6 | 1K22 | BC073237 | GD | |
| Phosphoribosyl pryophosphate synthetase 2 | 3C20 | BC045049 | NM | |
| Scaffold attachment factor A | 5J7 | BC084742 | NM, GD | |
| Strabismus | 14J18 | AF387816 | SB | |
| Tubulin folding cofactor B | 3I20 | BC106702 | NM | |
| Tyrosine phosphatase, Cdc25A | 14H20 | NM_001088487.1 | GD | |
| Uroplakin 1B | 18G1 | BC075147 | GD | |
| Yipf4 (yip1 domain containing protein) | 5J11 | BC070817 | GD, PD | |
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| ||||
| G. Unknown | Small EDRK-rich factor 2/4F5 | 6K23 | BC097837 | GD, K |
| Predicted protein with 2 HMG domains | 5B3 | BC108499 | AD, NM | |
| Immediate early response-5-like (IER5L) | 14B18 | BC106540 | SB, DD | |
| Similar to KIAA1826 isoform 2 | 1E18 | BC076739 | K, AD | |
| Predicted small nuclear phosphoprotein; DC13 | 3K20 | BC060385 | NM | |