Table 4. Upregulated pathways in Candida albicans keratitis compared with mock-infected controls.
| Signaling pathway | Log (p value) | Number of genes involved | Number upregulated genes | Ratio |
|---|---|---|---|---|
| Leukocyte extravasation |
16 |
191 |
44 |
0.23 |
| NF-κβ |
15.5 |
141 |
38 |
0.27 |
| Interleukin 10 |
13.2 |
68 |
23 |
0.34 |
| Interleukin 6 |
12.5 |
90 |
27 |
0.3 |
| Acute-phase response |
11.3 |
171 |
36 |
0.21 |
| B cell receptor |
6.7 |
144 |
26 |
0.18 |
| Toll-like receptor |
6.6 |
50 |
14 |
0.28 |
| Integrin |
6.1 |
188 |
30 |
0.16 |
| Natural killer cell |
6 |
112 |
19 |
0.17 |
| Granulocyte-macrophage colony-stimulating factor |
5.8 |
63 |
15 |
0.24 |
| Transforming growth factor beta |
4.9 |
84 |
16 |
0.19 |
| Chemokine |
4.7 |
75 |
15 |
0.2 |
| Interleukin 2 |
4.5 |
52 |
12 |
0.23 |
| Insulin-like growth factor 1 |
3.8 |
94 |
15 |
0.16 |
| T cell receptor |
3.5 |
100 |
15 |
0.15 |
| Epidermal growth factor |
3 |
47 |
9 |
0.19 |
| Vascular endothelial growth factor |
3 |
93 |
13 |
0.14 |
| Interleukin 4 |
3 |
69 |
11 |
0.16 |
| JAK/STAT |
2.6 |
112 |
19 |
0.17 |
| Apoptosis | 2.5 | 62 | 8 | 0.13 |