Table1.
Summary of genes represented more than once in a library of 272 insertion sites cloned from 20 lymphomas arising in MLV infected MYC/Runx2 transgenic mice
| Gene | # hits (tumors)1 | Known CIS2 | Product | Reported function relevant to cancer |
|---|---|---|---|---|
| Jdp2 | 16 (8) | Y | b-ZIP protein | Transformation, survival |
| Ccnd1 | 12 (9) | Y | Cyclin | Cell cycle, survival |
| Pim2 | 8 (6) | Y | Pim family protein kinase | Survival, proliferation |
| Rasgrp1 | 5 (4) | Y | Ras guanyl releasing protein | Proliferation, transformation |
| Pim1 | 4 (4) | Y | Pim family protein kinase | Survival, proliferation |
| Ccnd3 | 4 (4) | Y | Cyclin | Cell cycle, survival |
| Cstad | 4 (4) | Y | Mitochondrial protein | Mitochondrial biogenesis |
| Otx2 | 3 (3) | N | Homeodomain protein | Survival, tissue specification |
| Pik3r5 | 3 (2) | Y | PI3 kinase regulatory subunit | Survival, cell cycle |
| Tnfsf13b | 3 (2) | N | TNF family cytokine (Baff, BlyS) | Lymphocyte survival, cell cycle |
| Akt1 | 2 (2) | Y | Akt protein kinase | Survival, cell cycle |
| Bfsp2 | 2 (2) | N | Cytoskeletal protein | - |
| Ccrk | 2 (2) | N | Cell cycle related kinase (p42, PNQARLE) | Survival, cell cycle |
| Eif3s2 | 2 (2) | N | Translation initiation factor | Cell growth |
| Mad1l1 | 2 (2) | N | Mitotic spindle assembly checkpoint protein | Cell cycle |
| Rai17 | 2 (2) | Y | MIZ zinc finger domain | Localization to replication foci |
| Slc9a9 | 2 (2) | Y | Solute carrier | - |
| Ssbp3 | 2 (1) | Y | Single-stranded DNA binding | DNA replication |
1
Numbers in parenthesis represent number of tumors carrying gene specific insertions.
2
CIS, common insertion site