Figure 5. Asymmetric segregation in meiosis I of Cap-H2 mutants.

(A) Cap-H2^Z3-0019/Cap-H2^TH1 anaphase I where one pole appears to contain both X and Y chromosomes. This possibly represents failure in X/Y disjunction and subsequent co-segregation. Also note A', where a 4^th-to-heterolog thread exists. (B) Cap-H2^Z3-0019/Cap-H2^TH1 anaphase I where one pole contains only two large chromosomes. (C) Cap-H2^Z3-0019/Cap-H2^TH1 anaphase I where one pole contains only one major autosome and the Y chromosome. The other pole appears to carry an extra large chromosome. (D) Cap-H2^Z3-0019/Cap-H2^TH1 anaphase I where one pole contains only two large chromosomes. (E) Cap-H2^Z3-0019/Cap-H2^TH1 prophase I harboring an extra chromosome that may be the result of asymmetric anaphase I segregation. (F) Cap-H2^Z3-0019/Cap-H2^TH1 anaphase II with only one major autosome and the X chromosome. This suggests that an autosome was lost during anaphase I as a consequence of asymmetric segregation. (G) Cap-H2^Z3-0019/Cap-H2^TH1 anaphase II with an extra large chromosome. This may be a consequence of asymmetric segregation in anaphase I. The box at the bottom right illustrates the chromosome configuration.