Figure 3.
a. Array data were validated for selected target genes by quantitative real-time PCR (SYBR green). Adjacent bars show fold-regulation as measured by Affymetrix array and qt-RT-PCR as indicated. b. Bioinformatic analysis of the selected 50 Runx target genes (see also Table 1). The most common Gene Ontology terms and associated P values (http://david.abccncifcrf.gov/) are listed at the top of the figure. Top biological functions and associated P values were based on Ingenuity Pathways Analysis (www.ingenuity.com). The range of P values refer to sub-categories within each heading. The top two categories are listed for diseases and disorders, molecular and cellular functions, and physiological system development and function. The group numbers correspond to functional annotations listed in Table 1.
