. Author manuscript; available in PMC: 2008 Oct 7.

Published in final edited form as: Oncogene. 2008 Jun 16;27(44):5856–5866. doi: 10.1038/onc.2008.195

Table 1. Common target genes regulated by all three Runx family members.

List of 50 common target genes selected on the basis of similar regulation by Runx1, 2 and 3 and inducible regulation by RUNX1-ER . The basis of filtration of the gene sets is shown in Figure 2. Upregulated and downregulated genes are listed separately in alphabetical order. The fold-change levels estimated from duplicate chips are indicated for each Runx gene.

Gene name	Probe ID	GeneID	Gene	Runx1	Runx2	Runx3	Functional annotation^*
Up-regulated
Angiopoietin-like 4	1417130_s_at	NM_020581	Angptl4	2.14	1.85	2.28	1,4,6,9,11
Chemokine(C-C motif) ligand 2	1420380_at	AF065933	Ccl2	2.22	2	3.78	1,5,6,7,8,9,10,11
Chemokine(C-C motif) ligand 7	1421228_at	AF128193	Ccl7	2.92	2.34	3.29	1,5,6,8,9,10,11
Cytochrome P-450, family1, subfamily pptide1	1416612_at	B1251808	Cyp1b1	2.45	5.28	8.75	1,2,6
Elastin microfibril interfacer 1	1416414_at	NM_133918	Emilin1	3.17	4.4	9.14	1,5
IBR domain containing 3	1432478_a_at	AK015966	Ibrdc3	2.08	2.09	2.05
Integrin beta 5	1456195_x_at	BB543979	Itgb5	1.68	1.96	2.71	1,4,5,6,7,9,10,11
Lymphocyte antigen 6 containing complex	1453304_s_at	BM245572	Ly6e	2.8	3.06	2.02	1,9
Mannan-binding lectin serine protease 1	1425985_s_at	AB049755	Masp1	2.76	2.21	2.82	1
Neural cell adhesion molecule	1426865_a_at	BB698413	Ncam1	1.93	2.37	3.45	1,4,5,6,7,8,9,10
PCTAIRE-motif protein kinase 3	1449151_at	NM_008795	Pctk3	2.47	2.16	5.22
Retinol dehydrogenase 10 (all-trans)	1426968_a_at	BG073496	Rdh10	5.26	7.86	6.72
Response to complement gene 32	1418003_at	NM_025427	Rgc32	3.2	3.12	2.74	5
SERTA domain containing 4	1454877_at	BQ174721	Sertad4	3.05	2.46	4.3
Solute carrier family 40, member 1	1417061_at	AF226613	Slc40a1	2.78	1.99	6.18	2
ST3 β-galactoside alpha-2,3-sialyltransferase 5	1460241_a_at	BB829192	St3gal5	2.12	2.18	3.11	3
Tissue inhibitor of metalloproteinase 4	1423405_at	BI788452	Timp4	2.42	2.18	50.69	1,6,9,11
UDP-glucose ceramide transferase	1421269_at	AA591863	Ugcg	3.17	5.66	6.82	1,3,4,6,7
WW domain E3 ubiquitin protein ligase 2	1448145_at	AK004087	Wwp2	2.09	3.12	3.54
2610528A11Rik	1435639_at	BF580962	N/A	4.81	2.05	12.11
6330416G13Rik	1426315_a_at	AV326978	N/A	1.8	3.17	4.52

Down-regulated
Acid phosphatase-like 2	1456735_x_at	BB458645	Acpl2	−2.25	−2.25	−3.04
Adducin3 (γ)	1423297_at	BM239842	Add3	−1.68	−1.9	−2.68	5
Activated leukocyte cell adhesion molecule	1437467_at	AV315205	Alcam	−1.76	−2.16	−2.95	4,5,6
Cadherin-like 26	1456937_at	BB748621	Cdh26	−1.93	−3.52	−3.47	5
CCAAT/enhancer binding protein (C/EBP) δ	1423233_at	BB831146	Cebpd	−1.98	−3.32	−5.06	1,5,6,8,9,10
Erbb receptor feeback inhibitor 1 (MIG-6)	1416129_at	NM_133753	ErrFi1	−1.89	−2.24	−4.17	5,9
EGL nine homolog 3	1418649_at	BB284358	Egln3	−2.66	−2.07	−5.99	2,9
Enolase2, γ neuronal	1418829_a_at	NM_013509	Eno2	−1.87	−3.75	−3.89
Ferredoxin 1	1449108_at	D43690	Fdx1	−1.76	−2.26	−2.62	1
Fibronectin type III domain containing 3a	1426903_at	BC022140	Fndc3a	−1.69	−1.97	−2.64
Growth arrest specific 2	1450112_a_at	NM_00807	Gas2	−1.75	−2.17	−3.31	4,8,9,10
Inhibitor of DNA binding 2	1435176_a_at	BF19883	Id2	−3.21	−4.74	−6.55	4,5,6,7,8,9,10,11
Inhibitor of DNA binding 3	1416630_at	NM_008321	Id3	−2.33	−2.82	−2.64	4,5,6,8,9,10,11
Kit ligand	1415855_at	BB815530	Kitl	−1.63	−2.06	−2.69	1,5
Mesothelin	1460238_at	NM_018857	Msln	−1.82	−2.16	−4.92	1,9
Nuclear receptor subfamily 3, group C member 1^*	1457635_s_at	BB096079	Nr3c1	−1.72	−1.97	−2.66	5,7,8,10
Odd Oz/ten-m homologue 4	1434530_at	BQ175876	Odz4	−2.35	−2.37	−2.66	4
Phosphodiesterase 8B	1437989_at	BB357157	Pde8b	−2.46	−4.41	−11.13
Procollagen lys, 2-oxoglutarate 5-dioxygenase 2	1416686_at	BC021352	Plod2	−1.92	−2.31	−2.28	1,2
Paired related homeobox 1	1425527_at	L06502	Prrx1	−2.03	−1.7	−3.73	4,8,9,10
Receptor (calcitonin) activity modifying protein 3	1420401_a_at	NM_019511	Ramp3	−1.82	−2.02	−3.06	1,10
Regulator of G-protein signalling 2	1447830_s_at	BB034265	Rgs2	−3.55	−4.4	−10.54	9,10,11
Ring finger protein 144	1438404_at	BB125272	Rnf144	−2.63	−1.84	−2.76
Sphingosine-1-phosphate phosphatase 1	1420821_at	NM_030750	Sgpp1	−1.75	−2.11	−2.96	3,6
Signal induced proliferation-associated 1 like 2	1434261_at	AV228782	Sipa1l2	−1.77	−1.94	−2.32	5
Sine oculis-related homeobox 1 homologue	1427277_at	BB137929	Six 1	−2.83	−1.89	−3.42	4,5
Transducer of ERBB2, 2	1448666_s_at	AV174616	Tob2	−1.64	−1.84	−2.36	9
Vasoactive intestinal polypeptide	1428664_at	AK018599	Vip	−3.77	−4.18	−4.01	1,5
Xanthine dehydrogenase	1451006_at	AV286265	Xdh	−1.86	−2.51	−3.46	2,4,6,7,8,9,10

Gene	Probe ID	GeneID (1)	Gene ID (2)	Gene name	RUNX1-ER uniind.FR	RUNX1-ER unind.FDR
Esr1	1421244_at	NM_007956	Mm.9213	estrogen receptor 1 (alpha)	5.48	0

	1451382_at	BC025169	Mm.35083	1810008K03Rik	2.62	0

Mtus1	1436501_at	BB747681	Mm.149438	mitochondrial tumour suppressor 1	2.2	0.33
	1454824_s_at	BB699957	Mm.149438		1.75	0.76
	1436502_at	BB747681	Mm.149438		1.39	37.34

Gdap10	1420342_at	NM_010268	Mm.358597	Ganglioside-induced differentiation-associated-protein 10	2.38	0.25

	1451533_at	BC022687	Mm.186678	BC022687	1.97	0.4

Rx1t1	1437784_at	AW550878			2	0.5
Cbfa2t1h	1444615_x_at	AV327778	Mm.4909	CBFA2T1 identified gene homologue (human)	2.01	0.5
	1427640_a_at	X79989	Mm.4909		1.48	15.45
	1448785_at	BG072085	Mm.4909		1.4	37.34

Adm	1447839_x_at	AV378441	Mm.1408	Adrenomedullin	2.02	0.43
	1416077_at	NM_009627	Mm.1408		1.86	0.78

Lcp1	1415983_at	NM_008879	Mm.153911	lymphocyte cytosoloic protein 1	1.94	0.38

Ler3	14196347_a_at	NM_133662	Mm.25613	immediate early response 3	2	0.56

Arf6	1418824_at	BI24938	Mm.27308	ADP-ribosylation factor 6	2.19	0.67

	1422924_at	NM_009404		NM_009404	1.9	0.62

Functional annotation is based on the occurrence of each target gene in the sets defined in Figure 3b.