Table 4.
Adjusted and unadjusted association with DGF for inflammation and apoptosis related Polymorphisms [ND1]
| Polymorphism | Gene | Minor Allele [ND2] | Participants With Minor Allele (%) | Unadjusted OR (95% C.I.) | Adjusted OR (95 % C.I.) | |
|---|---|---|---|---|---|---|
| With DGF | Without DGF | |||||
| rs3024498 | IL10 | C | 107/281 (0.38) | 203/511 (0.4) | 0.93 (0.69 – 1.3) | 0.89 (0.62 – 1.3) |
| rs3024494 | IL10 | T | 3/282 (0.01) | 5/521 (0.01) | 1.1 (0.22 – 4.8) | 0.22 (0.02 – 3.3) |
| rs1878672 | IL10 | C | 157/253 (0.62) | 312/470 (0.66) | 0.83 (0.6 – 1.14) | 0.82 (0.56 – 1.2) |
| rs3024493 | IL10 | A | 56/262 (0.21) | 108/478 (0.23) | 0.93 (0.64 –1.3) | 1.1 (0.70 – 1.7) |
| rs1554286 | IL10 | A | 122/291 (0.42) | 209/514 (0.41) | 1.05 (0.79– 1.4) | 0.99 (0.70 – 1.4) |
| rs3021094 | IL10 | G | 48/260 (0.18) | 104/494 (0.21) | 0.85 (0.58– 1.2) | 0.90 (0.57 – 1.4) |
| rs2222202 | IL10 | A | 199/303 (0.66) | 378/548 (0.69) | 0.86 (0.64– 1.2) | 0.85 (0.60 – 1.2) |
| rs2071746 | HMOX1 | T | 216/294 (0.73) | 402/561 (0.72) | 1.1 (0.8– 1.5) | 0.99 (0.68 – 1.4) |
| (GT)n | HMOX1 | L | 205/326 (0.63) | 388/606 (0.64) | 0.95 (0.72– 1.3) | 1.2 (0.87 – 1.7) |
| rs2071747 | HMOX1 | C | 30/284 (0.11) | 48/522 (0.09) | 1.2 (0.71– 1.9) | 0.92 (0.53 – 1.6) |
| rs2071748 | HMOX1 | A | 191/293 (0.65) | 352/545 (0.65) | 1.0 (0.76– 1.4) | 1.09 (0.77 – 1.6) |
| rs8140669 | HMOX1 | A | 16/279 (0.06) | 26/508 (0.05) | 1.1 (0.58– 2.1) | 0.42 (0.13 – 1.3) |
| rs6518952 | HMOX1 | T | 20/297 (0.07) | 30/550 (0.05) | 1.3 (0.69– 2.2) | 0.49 (0.18 – 1.4) |
| rs2071749 | HMOX1 | G | 191/278 (0.69) | 344/506 (0.68) | 1.0 (0.76– 1.4) | 1.1 (0.74 – 1.6) |
| rs5755720 | HMOX1 | G | 146/295 (0.49) | 268/532 (0.5) | 0.97 (0.73– 1.3) | 1.0 (0.72 – 1.4) |
| rs2285112 | HMOX1 | G | 187/291 (0.64) | 332/515 (0.64) | 0.99 (0.73– 1.3) | 1.0 (0.72 –1.5) |
| rs9894946 | TP53 | T | 86/278 (0.31) | 145/519 (0.28) | 1.2 (0.84– 1.6) | 1.1 (0.75 – 1.6) |
| rs1614984 | TP53 | A | 187/277 (0.68) | 321/512 (0.63) | 1.24 (0.91– 1.69) | 1.3 (0.90 – 1.8) |
| rs17884306 | TP53 | T | 20/230 (0.09) | 35/440 (0.08) | 1.11 (0.61– 1.95) | 1.2 (0.57 – 2.4) |
| rs4968187 | TP53 | T | 4/290 (0.01) | 9/544 (0.02) | 0.85 (0.22– 2.68) | 0.67 (0.13 – 3.3) |
| rs12951053 | TP53 | C | 46/278 (0.17) | 62/507 (0.12) | 1.42 (0.94– 2.15) | 1.5 (0.90 – 2.6) |
| rs1625895 | TP53 | A | 78/278 (0.28) | 118/504 (0.23) | 1.28 (0.91– 1.78) | 1.2 (0.81 – 1.8) |
| rs1042522 | TP53 | C | 155/315 (0.49) | 260/584 (0.45) | 1.21 (0.92– 1.59) | 1.3 (0.92 – 1.8) |
| rs1800472 | TGFB1 | A | 10/292 (0.03) | 17/542 (0.03) | 1.1 (0.48– 2.42) | 0.92 (0.32– 2.6) |
| rs1982073 | TGFB1 | C | 163/256 (0.64) | 295/464 (0.64) | 1 (0.73– 1.38) | 0.91 (0.62 – 1.3) |
| rs1800629 | TNF | A | 84/294 (0.29) | 188/550 (0.34) | 0.77 (0.56– 1.05) | 0.84 (0.58 – 1.2) |
| rs3093662 | TNF | G | 53/303 (0.17) | 64/566 (0.11) | 1.66 (1.12– 2.47)* | 1.9 (1.2 – 3.0)* |
| rs3091257† | TNF | A | 43/229 (0.19) | 84/439 (0.19) | 0.98 (0.65– 1.47) | 1.5 (0.91 – 2.5) |
Adjusted for cold ischemia time, recipient race, extended criteria donor, donor cause of death, donor race, and source of DGF information (medical record or CMS claims or UNOS forms). The (GT)n SNP is categorized as short (S for ≤ 27 repeats) vs long repeats (L for >27 repeats
*
denotes p< 0.05
†
rs3091257 has been merged into rs1800628.[ND3]