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. Author manuscript; available in PMC: 2009 Sep 1.
Published in final edited form as: Exp Gerontol. 2008 Jul 9;43(9):813–819. doi: 10.1016/j.exger.2008.06.014

Figure 1. PGC-1α regulating network.

Figure 1

PGC-1α is at the center of a complex network of signals affected by metabolic, nutritional and environmental factors that modulate (e.g. through transcriptional and post-translational modifications) PGC-1α activity and thereby mitochondrial biogenesis. To date, very few negative regulators of PGC-1α have been found. However, increasing interest in this protein suggests the present regulatory network will grow yet more complex in the future.