Table 2.
Suppression of VEGF165 inhibits metastatic potentiala
| Visible lung metastasis |
Microscopic lung metastasis |
|||
|---|---|---|---|---|
| Cell lines | Incidenceb | Median no. of nodules (range) |
Incidenceb | Median no. of nodules (range) |
| LM7 | 7/7 | >200 (122 – >200) | 7/7 | >200 |
| LM7/si | 9/9 | 56 (12 – >200) | 9/9 | 43 (7 – >200) |
| LM7/siVEGF165 | 4/10 | 0 (0 – 15) | 6/10 | 0 (0 – 4) |
a
Mice were i.v. injected intravenously with the indicated cells (106). After 11 weeks, mice were sacrificed; lungs were removed, weighed, and fixed in 10% formalin. The number of visible and microscopic nodules were quantified.
b
Number of tumor-positive mice/per total number mice injected with cells.