Effect of PGE2 on the amplitude of evoked EPSCs induced by electrical stimulation of the solitary tract. A, Whole-cell voltage clamp recordings of EPSCs sampled from a NTS neuron. Solitary tract (ST) stimulation, 10 V, 150 μs; 0.2 Hz was elicited by placing a stimulating electrode on the ST ipsilateral to the recorded neuron. Each trace is an average of 10 ST-evoked EPSCs (evEPSCs). evEPSCs shown before (control), in the presence of 200 nM PGE2 and 15 min after switching to a drug-free aCSF (washout). B, group data showing that PGE2 significantly reduced the amplitude of the evEPSCs (*P < 0.01; n = 34). Error bars depict ± SEM.