Table 1.
Effect of PGE2 on the passive and active membrane properties. Overshoot measured from 0 mV to peak depolarization of the action potential (AP). Afterhyperpolarization (AHP) measured from the resting membrane potential to the maximal membrane hypepolarization. AP duration measured at one-half peak amplitude. The membrane input resistance shows a significant decrease (* P < 0.05, paired t-test) after PGE2 treatment. The apparent increase in the rheobase after PGE2 treatment was not significantly different (P > 0.05, paired t-test) owing to variability in the data set; 6 of the 10 NTS neurons showed no change. CTR denotes control; PGE2 bath applied at 100 nM. Numbers in parenthesis are number of neurons tested.
| AP Overshoot (mV) | AP AHP (mV) | AP duration (ms) | AP Threshold (mV) | Rheobase (pA) | Number AP at 2X Rheobase | Rin (MΩ) | |
|---|---|---|---|---|---|---|---|
| CTR | 64 ± 3.3 (n = 11) | −6 ± 2.2 (n = 11) | 1.1 ± 0.1 (n = 11) | −25 ± 2 (n = 11) | 44 ± 15 (n = 10) | 13.3 ± 2.2 (n = 12) | 540 ± 46.1 (n = 12) |
| PGE2 | 67 ± 4.4 (n = 11) | −7 ± 2.1 (n = 11) | 1.2 ± 0.1 (n = 11) | −27 ± 2 (n = 11) | 82 ± 26 (n = 10) | 17.9 ± 3.3 (n = 12) | 346 ± 46.0* (n = 12) |
*
P< 0.05