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. Author manuscript; available in PMC: 2009 Aug 5.
Published in final edited form as: Vaccine. 2008 Jun 13;26(33):4150–4159. doi: 10.1016/j.vaccine.2008.05.075

Figure 3. Replication of parental and chimeric viruses in mouse brain.

Figure 3

Five-day-old Swiss Webster mice were inoculated IC with 103 PFU of indicated virus. Brains were removed on odd days post-infection from four mice per group and virus titer was determined by plaque assay in Vero cells. Mean peak virus titers (log10PFU/g of brain) are indicated in parentheses. The limit of detection (101.7 PFU/g) is indicated by a dashed line. The end of a data line prior to day 21 indicates that all mice had succumbed to infection. The values for DEN4 are historical data included for comparison [10].