Table 2.
Virus | C/prM junction | Clone | Neuroinvasiveness in adult SCID mice LD50 (PFU)a | Neurovirulence in suckling SW mice LD50 (PFU)b |
---|---|---|---|---|
SLE | - | wt | 3.2 | 0.4 |
SLE/DEN4 | GGTR | 549 | <104 | >102 |
SLE/DEN4 | GGTR | 551 | >106 | 4.4 |
SLE/DEN4 | TSGR | 554 | >106 | >103 |
SLE/DEN4Δ30 | GGTR | 545 | >105 | 2.2 |
SLE/DEN4Δ30 | GGTR | 546 | >105 | 3.0 |
SLE/DEN4Δ30 | TSGR | 609 | >105 | 2.9 |
SLE/DEN4-436,437 | GGTR | 41 | >104 | >103 |
SLE/DEN4-654,655 | GGTR | 46 | >105 | 428 |
21 day-old SCID mice were inoculated intraperitoneally with serial 10-fold dilutions of indicated virus and then monitored for moribundity for 49 days.
3 day-old Swiss Webster mice were inoculated intracerebrally with serial 10-fold dilutions of indicated virus and then monitored for moribundity for 21 days.