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. Author manuscript; available in PMC: 2009 Aug 5.
Published in final edited form as: Vaccine. 2008 Jun 13;26(33):4150–4159. doi: 10.1016/j.vaccine.2008.05.075

Table 2.

Neuroinvasiveness and neurovirulence of SLE/DEN4 viruses in mice.

Virus C/prM junction Clone Neuroinvasiveness in adult SCID mice LD50 (PFU)a Neurovirulence in suckling SW mice LD50 (PFU)b
SLE - wt 3.2 0.4
SLE/DEN4 GGTR 549 <104 >102
SLE/DEN4 GGTR 551 >106 4.4
SLE/DEN4 TSGR 554 >106 >103
SLE/DEN4Δ30 GGTR 545 >105 2.2
SLE/DEN4Δ30 GGTR 546 >105 3.0
SLE/DEN4Δ30 TSGR 609 >105 2.9
SLE/DEN4-436,437 GGTR 41 >104 >103
SLE/DEN4-654,655 GGTR 46 >105 428
a

21 day-old SCID mice were inoculated intraperitoneally with serial 10-fold dilutions of indicated virus and then monitored for moribundity for 49 days.

b

3 day-old Swiss Webster mice were inoculated intracerebrally with serial 10-fold dilutions of indicated virus and then monitored for moribundity for 21 days.