Table 1.
Summary of the equilibrium and kinetic parameters [42]
Muscle PK | Kidney PK | Muscle PK | Kidney PK | ||
---|---|---|---|---|---|
L | 0.06±0.04 | 800±530 | 10000±3400 | 0.06±0.02 | |
60±6.8 | 64±9.3 | >50000 | 1.3±0.27 | ||
480±29 | 7000±3100 | 1.0±0.02 | 0.97±0.01 | ||
13000±5800 | 850±330 | 0.00 | 0.03 | ||
780±320 | 90±24 |
L=[ET]/[ER] is a unitless parameter. The K values are in μM and S, I and A are substrate (PEP), inhibitor (Phe) and activator (fructose-bis-phosphate, FBP) respectively. The k values are expressed as relative activity, 1.0 being equal Vmax.