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. Author manuscript; available in PMC: 2009 Jan 1.
Published in final edited form as: Nat Genet. 2008 Jun 8;40(7):862–870. doi: 10.1038/ng.157

Figure 1. Loss of Gata6 leads to lung epithelial differentiation defects.

Figure 1

Wild-type (WT) and Gata6 Δ/Δ :SP-C/cre mutants (SP-C/cre X G6 Δ/Δ) were examined by H+E staining (A–F) or by immunohistochemical staining for lung epithelial marker proteins.(G–N). Gata6 Δ/Δ :SP-C/cre mutants displayed dilated airways beginning as early as E12.5 (D and E, arrowheads). Gata6 Δ/Δ :SP-C/cre mutants showed decreased or absent expression of SP-C (G and K), CC10 (H and L), SP-B (I and M), and T lalpha (J and N). However, ectopic expression of the Clara cell marker protein CC10 was observed in distal regions of the airways of Gata6 Δ/Δ :SP-C/cre mutants (L, arrowheads). Asterisk indicates a large bronchiolar airway, which has reduced levels of CC10 expression in the mutants.