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. Author manuscript; available in PMC: 2008 Oct 7.
Published in final edited form as: Free Radic Biol Med. 2007 Apr 29;43(3):444–453. doi: 10.1016/j.freeradbiomed.2007.04.016

Figure 9. A Schema of the role of the antioxidant capability of curcumin in the inhibition of HSC activation.

Figure 9

Curcumin increases the level of intracellular GSH by inducing expression of GCL genes and stimulating the activity of GCL, leading to the attenuation of oxidative stress in activated HSC. These actions, together with others, reduce cell growth and fibrogenesis, resulting in the inhibition of HSC activation.