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Control (A) or Fzd5−/− embryos (B) carrying the TOPGAL transgene were analyzed by Xgal staining. Activation of the TOPGAL reporter is restricted to the dorsal optic vesicle in Fzd5−/− embryos at E9.5, similar to control embryos (A, B; arrowheads). Expression of Axin2 at 30 somites is restricted to the dorsal optic cup (arrowhead in C).
