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. Author manuscript; available in PMC: 2009 Feb 1.
Published in final edited form as: Hypertension. 2008 Jun 9;52(2):256–263. doi: 10.1161/HYPERTENSIONAHA.108.112706

Figure 2.

Figure 2

(A) Glomerular filtration rate (GFR), and (B) urinary albumin in CCR2+/+ and CCR2−/− mice infused with either vehicle or Ang II. GFR was similar in vehicle groups of both strains. In CCR2+/+ with Ang II-induced hypertension, GFR was significantly lower compared to vehicle (p<0.005, vehicle vs Ang II) and also compared to CCR2−/− with Ang II-induced hypertension (p < 0.005, CCR2+/+ vs CCR2−/−). In CCR2−/− with Ang II-induced hypertension, GFR did not change (NS; vehicle vs Ang II), (n = 11 to 13 per group). Urinary albumin excretion increased significantly in CCR2+/+ with Ang II-induced hypertension (p < 0.05, vehicle vs Ang II), while in CCR2−/−, it did not change. (n = 8 to 12 per group).