Comparison of pre- and post-supplementation phenotypic ratios (8-hour debrisoquine urinary recovery ratios) for CYP2D6. (A) Milk thistle, (B) Goldenseal, (C) Black cohosh, (D) Kava kava, (E) St. John's wort, and (F) Echinacea. Gray circles, Individual values; Black circles, Group means. Asterisks = statistically significant difference from baseline.