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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Mol Pharmacol. 2008 Apr 15;74(2):320–329. doi: 10.1124/mol.108.046458

Figure 4.

Figure 4

Rifampin concentration in plasma (○) and liver (Δ) of wildtype (A) and Slco1b2−/− (B) mice (n=5−6/time point) after a single intravenous dose of rifampin (1mg/kg). Steady-state rifampin concentration in liver (C) and plasma (D) in animals treated with continuous subcutaneous infusion of rifampin at a rate of 8 μg/hr over 24 hrs using Alzet Mini-osmotic pumps (n=4). Panel E shows the calculated liver to plasma ratio comparing wildtype and Slco1b2−/− animals. Data are expressed as mean ± SD.