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Liver-to-plasma ratio comparing wildtype and Slco1b2−/− animals following single intravenous dose of rifampin (1mg/kg)
| Time | wildtype | Slco1b2−/− |
|---|---|---|
| 5 min | 2.0 ± 1.2 | 0.6 ± 0.3 (*) |
| 15 min | 5.8 ± 2.9 | 1.6 ± 1.0 (*) |
| 30 min | 11.9 ± 6.7 | 2.4 ± 2.4 (*) |
| 1 h | 18.0 ± 16.6 | 3.0 ± 2.2 |
| 4 h | 4.7 ± 1.3 | 3.0 ± 0.4 (*) |
Data are expressed as mean liver-to-plasma ratio (mean ± SD)
p<0.05
