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Inhibition of [125I]RTI-55 binding to hDAT by SoRI-20041 (Panel A) and SoRI-2827 (Panel B). Three concentrations of [125I]RTI-55 were each displaced by 10 concentrations of SoRI-20041 or SoRI-2827. The data, expressed as percentage inhibition, were combined and analyzed for the best-fit estimates of the EMAX and EC50 (See Table 1) as described under Materials and Methods. Each point is the mean ± S.D. (n=4).
