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. Author manuscript; available in PMC: 2009 Jul 1.
Published in final edited form as: J Pharmacol Exp Ther. 2008 Apr 25;326(1):286–295. doi: 10.1124/jpet.108.139675

Figure 5.

Figure 5

Effect of SoRI-20041 on the hDAT BMAX and Kd. Two concentrations of [125I]RTI-55 (0.01 nM and 1.0 nM) were each displaced by ten concentrations of RTI-55 (.01 nM to 102 nM) in the absence and presence of the indicated concentrations of SoRI-20041. The data of three independent experiments were pooled and fit to a one site binding model for the best-fit estimates of the Kd and BMAX. Panel A. Effect of SoRI-20041 on the Kd and BMAX values expressed as a percent of control (±SD). Panel B. Percent increase in the Kd value produced by SoRI-20041. The Kd data in Panel A were fit to a one site binding model for the best-fit estimates of the EC50 and EMAX (±SD). * p<0.05 when compared to control (Students t-test).