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. Author manuscript; available in PMC: 2009 Jul 1.
Published in final edited form as: J Pharmacol Exp Ther. 2008 Apr 25;326(1):286–295. doi: 10.1124/jpet.108.139675

Figure 8.

Figure 8

Effect of SoRI-compounds on the VMAX of [3H]DA uptake in rat brain. Two concentrations of [3H]DA (2.0 nM and 20 nM) were each displaced by ten concentrations of DA (2 nM to 4096 nM) in the absence and presence of the indicated concentrations of test compounds. The data of three independent experiments were pooled and fit to a one site binding model for the best-fit estimates of the KM and VMAX. Panel A. Effect of SoRI-compounds on the VMAX values expressed as a percent of control (±SD). Panel B. Percent increase in the VMAX values produced by SoRI-compounds. The VMAX data in Panel A were fit to a one site binding model for the best-fit estimates of the EC50 and EMAX (±SD). * p<0.05 when compared to control (Students t-test).