Table 3.

Effect of SoRI-Compounds on the Dissociation of [¹²⁵I]RTI-55 from hDAT

Condition	One Component Fit K-1 (min-1)	Two Component Fit
A. SoRI-20040
RTI-55	0.055±0.002
SoRI-20040		A1 = 57±35 K-1 = 0.059±0.036 A2 = 41±36 K-2= 0.0047±0.013
RTI-55 + SoRI-20040	0.038±0.001*
B. SoRI-20041
RTI-55	0.066±0.003
SoRI-20041		A1 = 51±17 K-1 = 0.063±0.026 A2 = 46±18 K-2= 0±0.006
RTI-55 + SoRI-20041	0.038±0.001*
C. SoRI-2827
RTI-55	0.048±0.001
SoRI-2827		A1 = 67±19 K-1 = 0.064±0.022 A2 = 36±20 K-2= 0±0.008
RTI-55 + SoRI-2827	0.044±0.001

Dissociation experiments were conducted as described in Table 2 and Methods. Each parameter is ±SD.

^*p<0.05 when compared to the RTI-55 condition (Students t-test).