. Author manuscript; available in PMC: 2009 Jul 1.

Published in final edited form as: J Pharmacol Exp Ther. 2008 Apr 25;326(1):286–295. doi: 10.1124/jpet.108.139675

Table 4.

SoRI-Analogs Partially Inhibit [³H]DA Uptake Binding

	EC₅₀ (nM)	E_MAX (%)

GBR12909	8.8±1.5	120±7^*
Indatraline	6.6±0.6	105±2
SoRI-20040	3120±580	68±3^*
SoRI-20041	1770±130	77±1^*
SoRI-2827	2385±440	78±4^*

[³H]DA uptake into striatal synaptosomes was conducted as described in Methods. Ten point inhibition curves for were generated for each test drug using 5 nM [³H]DA. The data were transformed to percent inhibition and fit to the dose-response curve for the best-fit estimates of the EC₅₀ and E_MAX, using Kaleidagraph (Version 3.6.4). All curves were an n=3. Each value is ±SD.

p<0.05 when compared to indatraline (Students t-test).