TABLE 1.
Baseline Clinical Characteristics by Family History
| Characteristic | Sporadic Probands (n = 114) | Possible Familial Probands (n = 44) | Confirmed Familial Probands (n = 34) | Affected Relatives (n = 87) | *P-Value |
|---|---|---|---|---|---|
| Age at diagnosis (years) | 45.3 ± 10.9 | 42.8 ± 11.5 | 42.2 ± 13.6 | 46.1 ± 14.2 | 0.29 |
| Male gender | 93 (81.6) | 37 (84.1) | 21 (61.8) | 47 (54.0) | 0.03 |
| Ejection fraction (%) | 58.4 ± 7.9 | 57.8 ± 10.1 | 60.4 ± 8.5 | 60.4 ± 9.9 | 0.44 |
| ECG characteristics in sinus rhythm | |||||
| PR interval (ms) | 177.4 ± 31.8 | 169.5 ± 30.9 | 170.8 ± 22.7 | 166.0 ± 33.8 | 0.36 |
| QRS duration (ms) | 101.2 ± 20.8 | 101.5 ± 20.7 | 100.3 ± 20.0 | 96.2 ± 31.7 | 0.97 |
| QTc interval (ms) | 426.2 ± 31.5 | 428.8 ± 28.4 | 431.1 ± 27.7 | 427.1 ± 36.5 | 0.70 |
| QRS axis (°) | 19.3 ± 45.3 | 29.9 ± 38.3 | 35.3 ± 60.6 | 22.6 ± 56.7 | 0.17 |
| Ventricular rate (bpm) | 72.5 ± 24.1 | 72.1 ± 21.5 | 73.4 ± 15.9 | 73.3 ± 16.8 | 0.97 |
| Type of AF | 0.05 | ||||
| Paroxysmal | 76 (69.1) | 30 (68.2) | 17 (56.7) | 13 (28.9) | |
| Persistent | 25 (22.7) | 11 (25.0) | 5 (16.7) | 24 (53.3) | |
| Permanent | 9 (8.2) | 3 (6.8) | 8 (26.6) | 8 (17.8) | |
| Symptoms | |||||
| Palpitations | 47 (68.1) | 10 (76.9) | 14 (73.7) | 44 (73.3) | 0.77 |
| Awakened by palpitations at night | 25 (36.2) | 8 (61.5) | 7 (36.8) | 35 (53.0) | 0.22 |
| Dyspnea | 53 (74.6) | 10 (76.9) | 17 (89.5) | 25 (65.8) | 0.39 |
*
P-value is for comparison among sporadic, possible familial, and confirmed familial probands, excluding affected relatives.
Continuous variables are presented as mean ± SD; categorical variables are presented as no. (%).