Table III.

Calibration of the BRCAPRO predictions that exclude surviving all non-breast/ovary cancers versus including surviving all non-breast/ovary cancers. The first two columns are for predicting BRCA1 or BRCA2 mutations, the second for predicting solely BRCA1 mutations, the third for predicting solely BRCA2 mutations. The rows are for all the data (overall), those with carrier probability < 10%, and with carrier probability > 10%, computing the ratio of observed to expected (O/E) and the left/right endpoints of its 95% confidence interval.

		Predicting		Predicting		Predicting
		BRCA1 or BRCA2		BRCA1		BRCA2
		Excluding	Including	Excluding	Including	Excluding	Including
Overall	O/E	0.87	1.01	0.95	1.04	0.72	0.94
	Left 95%	0.79	0.93	0.85	0.93	0.59	0.77
	Right 95%	0.95	1.10	1.06	1.16	0.86	1.12
< 10%	O/E	3.2	3.8	2.9	3.4	1.4	1.8
	Left 95%	2.6	3.0	2.2	2.7	1.0	1.4
	Right 95%	4.0	4.6	3.6	4.2	1.9	2.4
> 10%	O/E	0.72	0.80	0.75	0.78	0.52	0.62
	Left 95%	0.65	0.73	0.66	0.69	0.41	0.47
	Right 95%	0.79	0.88	0.84	0.88	0.65	0.78