Table 1.
Differentially Expressed Probes in the Schizophrenic Patients of the Schizophrenia-enriched Cluster.
| Expression | Probe ID | Gene Name | p-value (t-Test) | FC Signed Magnitude | Gene Symbol |
| UP | 213920_at | Cut-like 2 (Drosophila) | 6.38E-06 | 2.77 | CUTL2 |
| UP | 215532_x_at | Zinc finger protein 492 | 1.30E-06 | 2.44 | ZNF492 |
| UP | 214735_at | Phosphoinositide-binding protein PIP3-E | 1.19E-04 | 2.4 | PIP3-E |
| UP | 220232_at | Stearoyl-CoA desaturase 4, biosynthesis of monounsaturated fatty acids from saturated fatty acids | 2.35E-05 | 2.34 | SCD4 |
| UP | 204730_at | Regulating synaptic membrane exocytosis 3 (RIMS3), Ca2+-binding C2 domain | 2.02E-04 | 2.22 | RIMS3 |
| UP | 216153_x_at | Reversion-inducing-cysteine-rich protein with kazal motifs | 1.92E-04 | 2.21 | RECK |
| UP | 216511_s_at | Transcription factor 7-like 2 (T-cell specific, HMG-box) (T-cellspecific transcription factor 4) | 1.04E-03 | 2.19 | TCF7L2(TCF4) |
| UP | 215182_x_at | mRNA; cDNA DKFZp586E121 (from clone DKFZp586E121) | 9.75E-04 | 2.12 | unknown |
| UP | 216037_x_at | Transcription factor 7-like 2 (T-cell specific, HMG-box) (T-cellspecific transcription factor 4) | 9.49E-05 | 2.04 | TCF7L2(TCF4) |
| UP | 215801_at | mRNA; cDNA DKFZp434G1615 (from clone DKFZp434G1615) | 7.57E-05 | 2.01 | unknown |
| UP | 222249_at | KIAA1651 protein | 1.03E-03 | 2.01 | unknown |
| DOWN | 209687_at | Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) | 2.79E-03 | -2.01 | CXCL12 |
| DOWN | 206662_at | Glutaredoxin (thioltransferase) | 2.70E-04 | -2.04 | GLRX |
| DOWN | 207768_at | Early growth response 4 | 8.53E-03 | -2.06 | EGR4 |
| DOWN | 208650_s_at | CD24 antigen (small cell lung carcinoma cluster 4 antigen) | 3.43E-04 | -2.21 | CD24 |
| DOWN | 203235_at | Thimet oligopeptidase 1 | 3.05E-03 | -2.25 | THOP1 |
| DOWN | 214432_at | ATPase, Na+/K+ transporting, alpha 3 polypeptide | 2.43E-04 | -2.28 | ATP1A3 |
| DOWN | 202802_at | Deoxyhypusine synthase | 3.39E-03 | -2.34 | DHPS |
| DOWN | 205626_s_at | Calbindin 1, 28 kDa | 5.36E-05 | -2.46 | CALB1 |
| DOWN | 219389_at | Hypothetical protein FLJ10052 | 6.06E-05 | -2.71 | FLJ10052 |
| DOWN | 266_s_at | CD24 antigen (small cell lung carcinoma cluster 4 antigen) | 3.91E-04 | -2.75 | CD24 |
| DOWN | 207307_at | 5-hydroxytryptamine(serotonin) receptor 2C | 1.49E-03 | -2.82 | HTR2C |
| DOWN | 208651_x_at | CD24 antigen (small cell lung carcinoma cluster 4 antigen) | 4.25E-05 | -2.92 | CD24 |
| DOWN | 206935_at | Protocadherin 8 | 1.46E-06 | -2.92 | PCDH8 |
| DOWN | 216379_x_at | CD24 antigen (small cell lung carcinoma cluster 4 antigen) | 4.17E-06 | -2.97 | CD24 |
| DOWN | 209771_x_at | CD24 antigen (small cell lung carcinoma cluster 4 antigen) | 2.30E-05 | -3.23 | CD24 |
Total 26 probes were determined as highly significantly affected independently from age and gender in schizophrenic patients of their specific cluster. Neurogenesis-related genes are shown in italics and cell maturation/migration-related genes are in bold. Note that calbindin, a maker for mature neurons in DG, is significantly downregulated in the schizophrenic patients.