Table 1. Intra- and inter-modular effects of mutations.

	Logic circuit model				RNA model
	Median±SE		p-value	Observed range	Median±SE		p-value	Observed Range
	FG	MVG			FG	MVG
Intra Module Effect	0.12±0.002	0.14±0.001	<10−4	0–0.2	0.28±0.007	0.36±0.005	<10−9	0.18–0.64
Inter Module Effect (Pleiotropy)	0.04±0.005	0.01±0.001	<10−4	0–0.1	0.057±0.005	0.053±0.005	NS	0.01–0.19

The first row corresponds to the normalized phenotypic effect of a genetic mutation on its own module; the second row corresponds to the normalized phenotypic effect of a genetic mutation within a module on the other modules (pleiotropy). The median±SE are presented for FG and MVG, p-value is as obtained from Wilcoxon rank sum test for equal medians. The range of effects in solution space was obtained by measuring the effects over a large random sample of genomes that solve G1 (see Text S1 section 3).